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Acute myocardial infarction following toxic epidermal necrolysis?
Author(s) -
Hirakawa,
Ohtsu,
Ojima,
Kouchi,
Uchida,
Kanzaki,
Arata
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00505.x
Subject(s) - medicine , toxic epidermal necrolysis , myocardial infarction , thrombocytosis , pathogenesis , rheumatoid arthritis , dermatology , disease , arthritis , culprit , platelet
We describe a 29‐year‐old woman with rheumatoid arthritis who suffered an acute myocardial infarction 70 days after an initial presentation with toxic epidermal necrolysis (TEN). The trigger for the TEN was probably an over‐the‐counter anti‐influenza treatment containing tipepidine hibenzate. Although the patient had familial hypercholesterolemia, we believe that thrombocytosis, induced by the inflammatory response and metabolic stress resulting from the TEN, may also have played a significant role in the pathogenesis of the myocardial infarction. Although TEN manifests itself principally as a skin disease, the potential for systemic morbidity, including cardiovascular abnormalities, should also be remembered.