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Bullous pemphigoid developing during systemic therapy with chloroquine
Author(s) -
Millard,
Stacy Smith,
Black,
Jonathan Barker
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00474.x
Subject(s) - bullous pemphigoid , medicine , dermatology , erythema multiforme , chloroquine , pemphigoid , sarcoidosis , pathology , immunology , antibody , malaria
Bullous pemphigoid has been reported to be induced or precipitated by systemic therapy with several drugs, including penicillamine, captopril, frusemide and ampicillin. We report an African male patient with sarcoidosis who was prescribed chloroquine for progressive dyspnoea. After 3 months he developed generalized pruritus which evolved into a widespread bullous eruption with acral targetoid lesions resembling erythema multiforme. The histological and immunofluorescence findings were diagnostic of bullous pemphigoid. The atypical clinical features of this case resemble the phenotype that has been noted in previous reports of drug‐induced bullous pemphigoid.