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Isoniazid induced pellagra despite pyridoxine supplementation
Author(s) -
A. Darvay,
T. Basarab,
Jane McGregor,
Robin RussellJones
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00444.x
Subject(s) - pellagra , pyridoxine , isoniazid , niacin , medicine , pyridoxine deficiency , complication , pediatrics , surgery , dermatology , pathology , tuberculosis
Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed — sometimes with life‐threatening consequences. We report a case of isoniazid‐induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. The possible mechanisms of isoniazid induced pellagra are discussed.