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Soluble E‐selectin serum levels correlate with disease activity in psoriatic patients
Author(s) -
Jacek C. Szepietowski,
F Wa̧sik,
E Bielicka,
Piotr Nockowski,
A Noworolska
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00401.x
Subject(s) - psoriasis , medicine , e selectin , l selectin , inflammation , immunology , disease , gastroenterology , cell adhesion molecule , adhesion , cell adhesion , chemistry , organic chemistry
E‐selectin is an adhesion molecule expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. It is responsible for the adherence between microvascular endothelium and neutrophils, monocytes, eosinophils and subsets of T cells. Soluble E‐selectin (sE‐selectin) serum levels were measured by ELISA in 32 psoriatic patients before treatment and compared with both post‐treatment sE‐selectin levels in 16 patients and sE‐selectin values in 10 healthy individuals. Soluble E‐selectin serum levels were significantly increased in psoriatic patients compared with healthy persons. Moreover, a significant correlation was demonstrated between sE‐selectin values and PASI scores. No relationship was found between sE‐selectin levels and duration of psoriasis. Soluble E‐selectin serum levels decreased significantly after treatment of psoriasis. This phenomenon was more evident in patients with more severe psoriasis. In conclusion, sE‐selectin serum levels correlate with the extent of psoriatic lesions and could be used as marker of the disease activity in psoriatic patients.