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Acute dysarthria induced by low dose methotrexate therapy in a patient with erythrodermic cutaneous T‐cell lymphoma: an unusual manifestation of neurotoxicity
Author(s) -
Aplin,
RussellJones
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00399.x
Subject(s) - medicine , methotrexate , discontinuation , neurotoxicity , dysarthria , dermatology , lymphoma , antimetabolite , chemotherapy , toxicity , surgery , radiology
Neurotoxicity has been associated on rare occasions with methotrexate therapy. We now report the case of a 71‐year‐old man with erythrodermic cutaneous T‐cell lymphoma who developed symptoms of dysarthria and inco‐ordination within 1 month of the initiation of oral methotrexate; discontinuation of the therapy then resulted in a gradual resolution of the problems.