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Combination therapy with nicotinamide and tetracyclines for cicatricial pemphigoid: further support for its efficacy
Author(s) -
Louise Reiche,
Fenella Wojnarowska,
E. Mallon
Publication year - 1998
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1998.00379.x
Subject(s) - minocycline , nicotinamide , medicine , nausea , tetracycline , dermatology , niacinamide , upper respiratory tract infection , surgery , gastroenterology , antibiotics , biochemistry , chemistry , microbiology and biotechnology , biology , enzyme
We have previously reported the reduction of cicatricial pemphigoid orodynia with minocycline. Tetracycline combined with high dose nicotinamide has also been beneficial in a number of cutaneous immunological disorders. We now report a series of eight cases in whom further subjective or clinical improvement accrued in five, after the addition of high dose (2.5 or 3 g) nicotinamide to minocycline; however, one of these then discontinued the nicotinamide because of headache and nausea, another was withdrawn from the study because of progressive upper respiratory tract mucosal involvement, and two were changed from minocycline to tetracycline because they developed minocycline‐induced hyperpigmentation.