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Atopic dermatitis apparently caused by Type 2 CD8+ T cells in an AIDS patient
Author(s) -
Norihisa Ishii,
Kazuo Takahashi,
Yasuyuki Sugita,
Hiroshi Nakajima
Publication year - 1998
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1998.00340.x
Subject(s) - atopic dermatitis , exacerbation , cd8 , immunology , eosinophilia , medicine , immunoglobulin e , immune system , dermatology , antibody
A patient with atopic dermatitis and acquired immune deficiency syndrome (AIDS) had demonstrated blood eosinophilia, high levels of serum IgE and intracytoplasmic IL‐4 in the CD8+ but not in the CD4+ cells, decreased numbers of CD4+ cells, and low levels of IL‐2 in both CD4+ and CD8+ cells. These results, reflecting a predominant influence of type 2 CD8+ cells, suggest they were involved in the genesis exacerbation of the patient's atopic dermatitis.