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No evidence for association between the −112G/A polymorphism of UGRP1 and childhood atopic asthma
Author(s) -
Jian Z.,
Nakayama J.,
Noguchi E.,
Shibasaki M.,
Arinami T.
Publication year - 2003
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1046/j.1365-2222.2003.01703.x
Subject(s) - asthma , genotype , transmission disequilibrium test , allele , atopy , immunology , medicine , population , etiology , proband , genetics , biology , single nucleotide polymorphism , gene , mutation , environmental health
Summary Background Susceptibility to asthma is known to involve genetic factors. Genome‐wide screens have indicated that the chromosome 5q31–q34 region is linked to and/or associated with asthma. A new gene, named UGRP1 and reported by Niimi et al., encodes uteroglobin‐related protein and is expressed in the lung and trachea. Niimi et al. showed the −112G/A polymorphism of the UGRP1 gene to be associated with asthma in a case–control study. Objective The objective of the present study was to replicate this association and confirm the possible role of the UGRP1 −112G/A polymorphism in the aetiology of childhood asthma in a Japanese population. Methods and results We conducted a transmission disequilibrium test (TDT) in 131 families identified through paediatric patients being treated for asthma. A case–control study was also carried out by comparing the probands and 137 unrelated non‐atopic non‐asthmatic Japanese children and 211 unrelated healthy Japanese adults. The −112G/A polymorphism was genotyped by the PCR‐RFLP method. The TDT revealed that the −112A allele was not preferentially transmitted to asthma‐affected children ( P =0.85). Neither the presence of at least one A allele in an individual's genotype (sum of the G/A and A/A genotypes) nor the −112A allele was more prevalent among the asthma subjects than among the control subjects. Conclusion Our findings indicate that the UGRP1 −112G/A polymorphism does not play a substantial role in genetic predisposition to childhood asthma in this Japanese population.