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Long‐term effects of corticosteroid nasal spray on nasal inflammatory cells in patients with perennial allergic rhinitis
Author(s) -
Adriaan Holm,
Tom Godthelp,
Wytske Fokkens,
E. A. W. F. M. Severijnen,
Paul Mulder,
Thea M. Vroom,
E. Rijntjes
Publication year - 1999
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1046/j.1365-2222.1999.00665.x
Subject(s) - medicine , fluticasone propionate , mucous membrane of nose , nasal spray , corticosteroid , eosinophil , placebo , budesonide , immunology , allergy , nasal lavage , gastroenterology , nasal administration , asthma , pathology , alternative medicine
Background The effect of long‐term topical nasal corticosteroid therapy on nasal inflammatory cells is unclear. Objectives To investigate the long‐term effect of fluticasone propionate aqueous nasal spray (FPANS) on nasal mucosal inflammatory cells and efficacy in a 1‐year study in patients with perennial allergic rhinitis. Methods In a 1‐year, double‐blind, placebo‐controlled study of duration we investigated the influence of a topical corticosteroid (FPANS), on Langerhans' cells (CD1a + cells), T cells, mast cells, eosinophils and macrophages in nasal mucosa in 42 patients with perennial allergic rhinitis. Efficacy was evaluated by nasal symptom score. Results The FPANS group experienced significantly less sneezing and nasal itching compared with the placebo group. The total symptom score in the FPANS group declined significantly in comparison with baseline ( P = 0.007) and placebo group ( P = 0.009). After 1 year of active treatment, a significant decrease was seen in the epithelium in numbers of Langerhans' cells, CD3 + , CD4 + , CD8 + cells, mast cells and eosinophils. In the lamina propria, there was a significant decrease in eosinophils. Conclusion These findings show that FPANS treatment results in a decrease of nasal inflammatory cells. Furthermore, the efficacy of FPANS improves after prolonged treatment.