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Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families
Author(s) -
Malcolm N. Blumenthal,
Stephen S. Rich,
Richard A. King,
James L. Weber
Publication year - 1998
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1046/j.1365-2222.1998.0280s1051.x
Subject(s) - pedigree chart , linkage (software) , genetics , genetic linkage , phenotype , biology , chromosome , gene , population , asthma , lod score , genetic heterogeneity , gene mapping , medicine , environmental health , immunology
Evidence for linkage of asthma and its associated phenotypes with susceptibility genes on chromosome 12 has been demonstrated in one group of Minnesota families. The evidence is strong in affected sib pairs and weakens in analysis of the large pedigrees. A second group of families provided little evidence for such linkage. A discrepancy has been demonstrated in different families. This may be due to several factors, including genetic heterogeneity and gene–gene, or gene–environmental interaction effects as well as the statistical power of the sample population used.