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Elevation of serum hepatocyte growth factor during granulocyte colony‐stimulating factor‐induced peripheral blood stem cell mobilization
Author(s) -
Fujii Keiko,
Ishimaru Fumihiko,
Kozuka Teruhiko,
Matsuo Keitaro,
Nakase Koichi,
Kataoka Itaru,
Tabayashi Takayuki,
Shinagawa Katsuji,
Ikeda Kazuma,
Harada Mine,
Tanimoto Mitsune
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04745.x
Subject(s) - hepatocyte growth factor , granulocyte colony stimulating factor , filgrastim , medicine , endocrinology , vascular endothelial growth factor , basic fibroblast growth factor , granulocyte , growth factor , cd34 , transplantation , stem cell , chemotherapy , biology , receptor , vegf receptors , genetics
Summary We examined serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. Granulocyte colony‐stimulating factor (G‐CSF) (filgrastim 400 μ g/m 2 /d) was administered to 23 donors for 5 d and aphereses were performed on days 4 and 5. Although bFGF remained at similar levels after G‐CSF treatment, serum VEGF and HGF levels increased 1·5‐fold ( n = 13; P = 0·02) and 6·8‐fold ( n = 23; P < 0·0001) respectively. The serum HGF level before G‐CSF administration on day 1 correlated inversely with mobilized CD34 + cell numbers. Time course kinetics of HGF showed that on the day after G‐CSF administration (day 2), serum HGF levels increased to 3678 pg/ml. For auto PBSC mobilization with chemotherapy and G‐CSF 200 μ g/m 2 /d ( n = 8), we observed similar HGF elevation, which appeared to be dose‐dependent on the G‐CSF administered.