Premium
Intravenous administration of replication‐incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance
Author(s) -
Wolins N.,
Lozier J.,
Eggerman T.L.,
Jones E.,
AguilarCórdova E.,
Vostal J. G.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04719.x
Subject(s) - platelet , in vivo , medicine , pharmacology , toxicity , immunology , biology , microbiology and biotechnology
Summary. A replication‐incompetent adenovirus vector was administered to rhesus macaques at 1, 3 and 6 × 10 12 particles/kg doses to investigate its toxicity. Platelet count decrements of 28%, 82% and 90%, respectively, were observed, with corresponding platelet half‐lives of 69·0, 25·2 and 22·2 h (compared with 111 h in untreated animals). The platelet decline was equivalent for all three doses for 8 h, and platelet count recovery began as early as 8 h after infusion for low‐dose recipients, or as late as 24 h for the medium and high dose recipients. These observations suggest that thrombocytopenia is a saturable, reversible consumptive process.