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Frequent aberrant promoter hypermethylation of O 6 ‐methylguanine‐DNA methyltransferase and death‐associated protein kinase genes in immunodeficiency‐related lymphomas
Author(s) -
Rossi Davide,
Gaidano Gianluca,
Gloghini Annunziata,
Deambrogi Clara,
Franceschetti Silvia,
Berra Eva,
Cerri Michaela,
Vendramin Chiara,
Conconi Annarita,
Viglio Alessandra,
Muti Giuliana,
Oreste Pierluigi,
Morra Enrica,
Paulli Marco,
Capello Daniela,
Carbone Antonino
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04644.x
Subject(s) - methyltransferase , o 6 methylguanine dna methyltransferase , dna , dna methylation , cancer research , microbiology and biotechnology , gene , dna methyltransferase , methylation , biology , genetics , gene expression
Summary. Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)‐non Hodgkin lymphomas (NHL), 25 post‐transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)‐related NHL. Twenty‐six of 79 (32·9%) HIV‐NHL, eight of 14 (57·1%) PTLD and two of five (40·0%) CVI–NHL showed aberrant hypermethylation of O 6 ‐methylguanine‐DNA methyltransferase ( MGMT ). Aberrant hypermethylation of death‐associated protein‐kinase ( DAP‐K ) occurred in 70 of 84 (83·3%) HIV–NHL, 19 of 25 (72·0%) PTLD and three of five (60·0%) CVI–NHL. These data implicate MGMT and DAP‐K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP‐K represents the most frequent molecular alteration yet identified in immunodeficiency‐related lymphomas.