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The polycythaemia rubra vera‐1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders
Author(s) -
Bock Oliver,
Serinsöz Ebru,
Neusch Michael,
Schlué Jerome,
Kreipe Hans
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04641.x
Subject(s) - polycythaemia , polycythemia vera , haematopoiesis , bone marrow , myeloproliferative disorders , cancer research , medicine , myeloid , immunology , myeloproliferative neoplasm , downregulation and upregulation , biology , gene , myelofibrosis , stem cell , genetics
Summary. Little is known about the expression of the polycythaemia rubra vera‐1 ( PRV‐1 ) gene in bone marrow cells. To determine the expression level of PRV‐1 in the bone marrow, we analysed PRV‐1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. We demonstrated that PRV‐1 was constitutively expressed in both myeloproliferative and reactive states. We concluded that, rather than an upregulation of the PRV‐1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV‐1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.