Premium
Hypoxic response of iron absorption is not affected by the Hfe gene knock‐out in mice
Author(s) -
Laftah Abas H.,
Simpson Robert J.,
Beaumont Nick,
Bahram Seiamak,
Schümann Klaus,
Srai S. Kaila S.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04559.x
Subject(s) - hypoxia (environmental) , chemistry , absorption (acoustics) , in vivo , hemochromatosis , oxygen , knockout mouse , gene , microbiology and biotechnology , biology , biochemistry , genetics , materials science , organic chemistry , composite material
Summary. The effect of Hfe (haemochromatosis) gene deletion on the hypoxic response of iron absorption was investigated. Hfe knock‐out mice were exposed to 0·5 atmospheres hypoxia for 3 d before in vivo iron absorption was measured. Both wild‐type and Hfe knock‐out mice had similar (two‐ to threefold) increases in iron absorption in response to hypoxia. We conclude that the Hfe gene product is not required for mice to increase iron absorption rates in response to hypoxia. The data further support the hypothesis that at least two independent mechanisms for the regulation of iron absorption exist, only one of which requires Hfe .