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Severe and selective deficiency of interferon‐γ‐producing invariant natural killer T cells in patients with myelodysplastic syndromes
Author(s) -
Fujii Shinichiro,
Shimizu Kanako,
Klimek Virginia,
Geller Matthew D.,
Nimer Stephen D.,
V. Dhodapkar Madhav
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04465.x
Subject(s) - natural killer t cell , immunology , cd8 , interferon , myelodysplastic syndromes , biology , natural killer cell , cytotoxic t cell , immune system , cancer research , medicine , bone marrow , biochemistry , in vitro
Summary. Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24 + /Vβ11 + natural killer T (NKT) cells, but not NK cells or CD4 + or CD8 + T cells. Neither the blood nor marrow of MDS patients had detectable interferon‐γ‐producing NKT cells in response to the NKT ligand, α‐galactosyl ceramide, although influenza‐virus‐specific effector T‐cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.