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Increasing oxygen tension improves filtration of sickle trait donor blood
Author(s) -
Byrne Karen M.,
Leitman Susan F.,
Schechter Alan N.,
Stroncek David F.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04464.x
Subject(s) - sickle cell trait , filtration (mathematics) , oxygen tension , red cell , oxygen , red blood cell , air filtration , medicine , surgery , chemistry , mathematics , statistics , disease , organic chemistry , particulates
Summary. A major cause of filter failure of red cell (RBC) components from donors with sickle cell trait (HbAS) is the polymerization of haemoglobin. The oxygen saturation (sO 2 ) of blood stored in various plastics and different volumes of air was assessed. Blood from 10 HbAS donors was collected and divided into two bags, one with air added, one without. Bags with added air had increased sO 2 levels (from 49 ± 10% to 76 ± 6%). Filtration was successful for nine of 10 components with air, and one of 10 without air. Successful filtration of RBC components occurs when sO 2 is increased.