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Expression of cox‐2, tie‐2 and glycodelin by megakaryocytes in patients with chronic myeloid leukaemia and polycythaemia vera
Author(s) -
Zetterberg Eva,
Lundberg Lars Göran,
Palmblad Jan
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04289.x
Subject(s) - polycythaemia , megakaryocytopoiesis , medicine , polycythemia vera , bone marrow , angiogenesis , chronic myeloid leukaemia , pathology , haematopoiesis , myeloid , pleiotrophin , megakaryocyte , immunology , cancer research , biology , stem cell , growth factor , receptor , genetics
Summary. When evaluating bone marrow sections for markers of neo‐angiogenesis, we found that megakaryocytes stained markedly positive for cyclooxygenase‐2 (Cox‐2), Tie‐2 and glycodelin. This apparently novel finding was further evaluated for disease‐specific variations. Bone marrow sections from two patient groups, known to be characterized by clonal megakaryocytopoiesis, viz . chronic myeloid leukaemia and polycythaemia vera, stained, however, similarly to healthy marrows for these markers. The biochemical background and clinical significance of Cox‐2, Tie‐2 and glycodelin remains to be elucidated.