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Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus
Author(s) -
Calverley David C.,
Hacker Michele R.,
Loda Kimberly A.,
Brass Elizabeth,
Buchanan Thomas A.,
TsaoWei Denice D.,
Groshen Susan
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04233.x
Subject(s) - platelet , platelet activation , diabetes mellitus , medicine , endocrinology , collagen receptor , flow cytometry , receptor , stimulation , receptor expression , thrombosis , syk , fc receptor , immunology , tyrosine kinase , integrin alpha m
Summary. Recent clinical and laboratory observations support a potential role for the platelet FcγRIIA receptor (FcR) in collagen‐mediated platelet activation associated with arterial thrombosis. Stable age‐ and sex‐independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non‐diabetes patients ( P < 0·001). Aggregation studies following FcR cross‐linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation ( P = 0·018). Immunoprecipitation of collagen‐stimulated and FcR‐crosslinked platelets demonstrated enhanced levels of tyrosine‐phosphorylated Syk in diabetic platelets. Increased platelet FcR‐mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.