Premium
Over‐expression of short isoforms of Helios in patients with adult T‐cell leukaemia/lymphoma
Author(s) -
Fujii Keiko,
Ishimaru Fumihiko,
Nakase Koichi,
Tabayashi Takayuki,
Kozuka Teruhiko,
Naoki Kyoko,
Miyahara Masayuki,
Toki Hironobu,
Kitajima Koichi,
Harada Mine,
Tanimoto Mitsune
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04216.x
Subject(s) - gene isoform , lymphoma , medicine , immunology , gene , human t lymphotropic virus 1 , virus , cancer research , t cell leukemia , biology , genetics
Summary. In previous studies, we demonstrated an over‐expression of the dominant‐negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B‐cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over‐expression of the short isoforms of Helios , which is one of the members of the Ikaros gene family, in a patient with T‐cell ALL. In the present study, we found over‐expression of short isoforms of Helios in human T lymphotropic virus‐I (HTLV1)‐infected patients who had developed chronic and acute forms of adult T‐cell leukaemia/lymphoma. In contrast, we could not detect any over‐expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T‐cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.