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Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia
Author(s) -
Morris Emma C.,
Harrison Georgina,
Bailey Clifford C.,
Hann Ian M.,
Hill Frank G.,
Gibson Brenda E. S.,
Richards Susan,
Webb David K. H.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04158.x
Subject(s) - medicine , central nervous system , pediatrics , acute lymphocytic leukemia , disease , el niño , lymphoblastic leukemia , leukemia
Summary. The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3702 children with ALL between January 1985 and March 1997. Seventy‐nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow‐up of 22 months from second relapse; seven (9%) in third remission, two in later remissions and five with disease. Factors predictive of survival from second relapse were site (isolated CNS was better than combined CNS, P = 0·02) and time from diagnosis to second CNS relapse (longer time was better, P = 0·004). Prognosis after second CNS relapse is extremely poor, and palliative therapy is appropriate.