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A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony‐stimulating factor: significant effects on quality of life
Author(s) -
HellströmLindberg Eva,
Gulbrandsen Nina,
Lindberg Greger,
Ahlgren Tomas,
Dahl Inger Marie S.,
Dybedal Ingunn,
Grimfors Gunnar,
HesseSundin Eva,
Hjorth Martin,
KanterLewensohn Lena,
Linder Olle,
Luthman Michaela,
Löfvenberg Eva,
Öberg Gunnar,
PorwitMacDonald Anja,
Rådlund Anders,
Samuelsson Jan,
Tangen Jon Magnus,
Winquist Ingemar,
Wisloff Finn
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04153.x
Subject(s) - medicine , erythropoietin , granulocyte colony stimulating factor , confidence interval , myelodysplastic syndromes , quality of life (healthcare) , anemia , population , gastroenterology , oncology , chemotherapy , bone marrow , nursing , environmental health
Summary. We have published previously a prototype of a decision model for anaemic patients with myelodysplastic syndromes (MDS), in which transfusion need and serum erythropoietin (S‐Epo) were used to define three groups with different probabilities of erythroid response to treatment with granulocyte colony‐stimulating factor (G‐CSF) + Epo. S‐Epo ≤ 500 U/l and a transfusion need of < 2 units/month predicted a high probability of response to treatment, S‐Epo > 500 U/l and ≥ 2 units/month for a poor response, whereas the presence of only one negative prognostic marker predicted an intermediate response. A total of 53 patients from a prospective study were included in our evaluation sample. Patients with good or intermediate probability of response were treated with G‐CSF + Epo. The overall response rate was 42% with 28·3% achieving a complete and 13·2% a partial response to treatment. The response rates were 61% and 14% in the good and intermediate predictive groups respectively. The model retained a significant predictive value in the evaluation sample ( P < 0·001). Median duration of response was 23 months. Scores for global health and quality of life (QOL) were significantly lower in MDS patients than in a reference population, and fatigue and dyspnoea was significantly more prominent. Global QOL improved in patients responding to treatment ( P = 0·01). The validated decision model defined a subgroup of patients with a response rate of 61% (95% confidence interval 48–74%) to treatment with G‐CSF + Epo. The majority of these patients have shown complete and durable responses.