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Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna‐12
Author(s) -
Pruneri Giancarlo,
Bertolini Francesco,
Baldini Luca,
Valentini Stefano,
Goldaniga Maria,
Soligo Davide,
Carboni Nadia,
Viale Giuseppe,
LambertenghiDeliliers Giorgio
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04133.x
Subject(s) - angiogenesis , cd34 , medicine , bone marrow , endoglin , monoclonal antibody , pathology , microvessel , nod , immunology , cancer research , antibody , biology , stem cell , endocrinology , genetics , diabetes mellitus
Summary. Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti‐CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non‐obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna‐12. The anti‐CD105 Ab was significantly more sensitive than anti‐CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon‐α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.