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Paradoxical association between the 316 Trp to Ser beta 2‐glycoprotein I (Beta2GPI) polymorphism and anti‐Beta2GPI antibodies
Author(s) -
Nash Michael J.,
Camilleri Raymond S.,
Liesner Ri,
Mackie Ian J.,
Machin Samuel J.,
Cohen Hannah
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04130.x
Subject(s) - antibody , genotyping , medicine , anticardiolipin antibodies , immunology , endocrinology , gastroenterology , genotype , biology , genetics , gene
Summary. We report a woman with an obstetric history ofa stillbirth at 28 weeks, associated with hypertension and severe intrauterine growth restriction and a miscarriage at 9 weeks. She was persistently positive for immunolgobulin G (IgG) anticardiolipin antibodies and IgG anti‐Beta‐2‐glycoprotein I (anti‐Beta2GPI) antibodies. She has delivered three healthy babies when managed antenatally with aspirin and low‐molecular‐weight heparin prophylaxis. Genotyping revealed that she was homozygous for the 316 Trp to Ser Beta2GPI polymorphism. Studies examining the binding of her plasma Beta2GPI to purified cardiolipin showed markedly reduced binding in comparison with Beta2GPI in pooled normal plasma.