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Expansion of CD8 + T cells that express low levels of the B cell‐specific molecule CD20 in patients with multiple myeloma
Author(s) -
Katopodis Ourania,
Liossis StamatisNick,
Viglis Vassilios,
Pouli Anastasia,
Dimopoulos MeletiosAthanasios,
Sfikakis Petros P.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04087.x
Subject(s) - cd20 , multiple myeloma , cytotoxic t cell , cd8 , bone marrow , monoclonal gammopathy of undetermined significance , plasma cell , medicine , cd3 , t cell , cd38 , b cell , immunology , cd19 , monoclonal , biology , antigen , monoclonal antibody , immune system , antibody , cd34 , stem cell , microbiology and biotechnology , biochemistry , in vitro
Summary. An expanded cytotoxic/memory T‐cell subpopulation expressing low levels of the B‐cell‐specific CD20 molecule was found in peripheral blood and bone marrow of patients with multiple myeloma at the time of diagnosis, but returned to normal levels following treatment. CD3 + CD20 dim cells were also increased in monoclonal gammopathy of unknown significance albeit at lower levels. Lower CD3 + CD20 dim cell numbers at baseline may be associated with lack of response to treatment and a poor outcome. Because expansion of these T cells may be related to disease status, further studies should investigate their potentially unique function in plasma cell dyscrasias.