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Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates
Author(s) -
JilmaStohlawetz Petra,
Homoncik Monika,
Jilma Bernd,
Knechtelsdorfer Maarten,
Unger Petra,
Mannhalter Christine,
Santoso Sentot,
Panzer Simon
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04083.x
Subject(s) - genotype , platelet membrane glycoprotein , platelet , allele , glycoprotein , polymorphism (computer science) , polymerase chain reaction , immunology , genetics , microbiology and biotechnology , medicine , biology , chemistry , gene
Summary. Platelet polymorphisms (Kozak, VNTR and HPA‐2) within glycoprotein (GP)Ibα may be associated with an increased risk of arterial thrombosis. However, the functional role of these polymorphisms has not been clarified. Their influence on platelet plug formation under high shear rates was, therefore, examined in 233 healthy individuals. Collagen–adrenaline‐induced closure time was shorter in carriers of the C/D versus C/C VNTR allele and in homozygotes with the (−5)T/T versus (−5)C/T Kozak genotype as determined by novel polymerase chain reaction methods. The HPA‐2 genotype had no effects, and the density of GPIbα molecules was not influenced by GPIbα genotypes.