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Common clonal T‐cell origin in a patient with T‐prolymphocytic leukaemia and associated cutaneous T‐cell lymphomas
Author(s) -
Assaf Chalid,
Hummel Michael,
Dippel Edgar,
Schwartz Stefan,
Geilen Christoph C.,
Harder Lana,
Siebert Reiner,
Steinhoff Matthias,
Klemke ClausDetlev,
Thiel Eckhard,
Goerdt Sergij,
Stein Harald,
Orfanos Constantin E.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04072.x
Subject(s) - lymphomatoid papulosis , prolymphocytic leukemia , mycosis fungoides , clone (java method) , gene rearrangement , anaplastic large cell lymphoma , lymphoma , peripheral t cell lymphoma , biology , cancer research , pathology , t cell , medicine , leukemia , immunology , gene , genetics , immune system , chronic lymphocytic leukemia
Summary. An unusual course was observed in a patient with indolent T‐prolymphocytic leukaemia (T‐PLL) who subsequently developed mycosis fungoides (Mf), lymphomatoid papulosis (LyP) and cutaneous CD30 + anaplastic large cell lymphoma (ALCL). Polymerase chain reaction analysis demonstrated identical monoclonal T‐cell receptor‐β and ‐γ gene rearrangements in all the different clinical entities. Furthermore, cytogenetic studies revealed the same aberrant clone with trisomy of chromosome 8 in T‐PLL and ALCL cells. This unique observation suggests that in T‐PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T‐cell lymphoma.