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Macrophage inflammatory protein‐1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM
Author(s) -
Uneda Shima,
Hata Hiroyuki,
Matsuno Fumihiko,
Harada Naoko,
Mitsuya Yumi,
Kawano Fumio,
Mitsuya Hiroaki
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04040.x
Subject(s) - multiple myeloma , bone marrow , chemokine , macrophage inflammatory protein , pathogenesis , pathology , myeloma protein , immunohistochemistry , macrophage , alpha (finance) , medicine , immunology , inflammation , biology , in vitro , biochemistry , construct validity , nursing , patient satisfaction
Summary. Macrophage inflammatory protein‐1 alpha (MIP‐1α) is a chemokine primarily associated with bone absorption. We examined whether MIP‐1α was produced by purified fresh tumour cells isolated from bone marrow samples from 31 multiple myeloma (MM) patients. High levels of MIP‐1α were found in supernatants of myeloma cell cultures. Immunohistochemical staining showed MIP‐1α in the cytoplasm of myeloma cells. MIP‐1α mRNA expression was detected in 18 of 31 patients. Bone lesions were seen in 16 of the 18 MIP‐1α‐positive patients but only in six of the 13 MIP‐1α‐negative patients ( P = 0·0097,χ 2 ‐test). The data indicate that MIP‐1α is produced by myeloma cells and possibly plays a role in the pathogenesis of bone lesions in MM patients.