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High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation
Author(s) -
Chuang ShihSung,
Lee Chuan,
Hamoudi Rifat A.,
Liu Hongxiang,
Lee PoShing,
Ye Hongtao,
Diss Tim C.,
Dogan Ahmet,
Isaacson Peter G.,
Du MingQing
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04035.x
Subject(s) - malt lymphoma , chromosomal translocation , lymphatic system , lymphoma , mucosa associated lymphoid tissue , pathology , gastric mucosa , gastric lymphoma , malignant transformation , medicine , biology , gastroenterology , stomach , gene , genetics
Summary. t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa‐associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients.Although the translocation is often associated with an ‘aggressive’ course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high‐grade transformation and 11 diffuse large B‐cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high‐grade transformation, showed the translocation in low‐ and high‐grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.