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Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia
Author(s) -
Takeuchi Seisho,
Takeuchi Naoko,
Tsukasaki Kunihiro,
Bartram Claus R.,
Zimmermann Martin,
Schrappe Martin,
Taguchi Hirokuni,
Koeffler H. Phillip
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03964.x
Subject(s) - haplotype , immunophenotyping , locus (genetics) , lymphoma , tumor necrosis factor alpha , immunology , medicine , oncology , biology , genetics , genotype , gene , antigen
Summary. Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non‐Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high‐risk haplotype were older than patients with low‐risk haplotype ( P = 0·024). No statistically significant associations were found between TNF haplotype and sex, WBC counts, central nervous system involvement, immunophenotype, response to chemotherapy, and event‐free survival. These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL.