Premium
Clonal T cell‐mediated cyclic thrombocytopenia
Author(s) -
Füreder Wolfgang,
Mitterbauer Gerlinde,
Thalhammer Renate,
Geissler Klaus,
Panzer Simon,
Krebs Michael,
SimonitschKlupp Ingrig,
Sperr Wolfgang R.,
Lechner Klaus,
Kyrle Paul A.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03951.x
Subject(s) - thrombopoiesis , platelet , thrombopoietin , bone marrow , bone marrow failure , immunology , medicine , biology , endocrinology , megakaryocyte , haematopoiesis , stem cell , microbiology and biotechnology
Summary. Cyclic thrombocytopenia is a rare disorder characterized by periodic platelet count fluctuations of unknown aetiology. We report on a female patient with cyclic changes of platelet counts ranging from 6 × 10 9 /l to 753 × 10 9 /l in 4‐week intervals. Platelet counts were inversely correlated to thrombopoietin levels suggesting production failure. Reticulocyte counts and neutrophil counts showed similar, but less prominent, fluctuations. Clonal T‐cell receptor rearrangement was detected in bone marrow samples as well as in peripheral blood. Cell typing of blood lymphocytes revealed a relative increase in CD3 + T cells. Treatment with cyclosporine A resulted in a substantial improvement of platelet counts. Taken together, we provide evidence for clonal T‐cell mediated bone marrow failure with cyclic impairment of thrombopoiesis responsive to cyclosporine therapy.