Premium
Helicobacter pylori infection and monoclonal gammopathy of undetermined significance
Author(s) -
Rajkumar S. Vincent,
Kyle Robert A.,
Plevak Matthew F.,
Murray Joseph A.,
Therneau Terry M.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03912.x
Subject(s) - monoclonal gammopathy of undetermined significance , helicobacter pylori , medicine , gastroenterology , serology , monoclonal , concomitant , immunology , pathology , monoclonal antibody , antibody
Summary. A recent report found resolution of monoclonal gammopathy of undetermined significance (MGUS) in nearly 30% of patients upon eradication of concomitant Helicobacter pylori ( H. pylori ) infection. We performed serologicalal testing for H. pylori on 93 MGUS patients and 98 control subjects. Seroprevalence of H. pylori was not significantly different between the two groups, 30% and 32% respectively. A retrospective review of Mayo Clinic records revealed identical diagnosis rates of H. pylori infection (33%) by serology, breath or stool testing between patients with MGUS and those with negative monoclonal protein studies. There was no evidence of resolution of MGUS with H. pylori therapy.