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CXCL13 (BCA‐1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells
Author(s) -
Husson Hervé,
S. Freedman Arnold,
A. Cardoso Angelo,
Schultze Joachim,
Munoz Olivier,
Strola Giuliana,
Kutok Jeffery,
G. Carideo Elizabeth,
De Beaumont Rosalie,
CaligarisCappio Federico,
Ghia Paolo
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03832.x
Subject(s) - cxcl13 , cxcr5 , follicular lymphoma , chemokine , stromal cell , follicular phase , follicular dendritic cells , lymphoma , microbiology and biotechnology , cc chemokine receptors , cancer research , chemokine receptor , chemistry , biology , receptor , immunology , endocrinology , t cell , antigen presenting cell , biochemistry , immune system
Summary. Follicular lymphomas (FLs) localize in lymphoid tissues and recapitulate the structure of normal secondary follicles. The chemokine/chemokine receptor pair CXCL13/CXCR5 is required for the architectural organization of B cells within lymphoid follicles. In this study, we showed that CXCL13 was secreted by FL cells. FL cells expressed CXCR5 and migrated in response to CXCL13. Furthermore, we observed a synergistic effect between CXCL13 and CXCL12 (SDF‐1), a chemokine produced by stromal cells in lymphoid tissues. The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites.