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Frequent co‐expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement
Author(s) -
Imamura Toshihiko,
Morimoto Akira,
Takanashi Mami,
Hibi Shigeyoshi,
Sugimoto Tohru,
Ishii Eiichi,
Imashuku Shinsaku
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03803.x
Subject(s) - gene , gene rearrangement , lymphoblastic leukemia , medicine , cancer research , biology , genetics , leukemia
Summary. We studied the expression of HoxA9 and Meis1 by reverse transcriptase‐polymerase chain reaction analysis in leukaemic cells from cases of infant acute lymphoblastic leukaemia (ALL, n = 27) and childhood ALL ( n = 29). These two genes were co‐expressed significantly more frequently in infant ALL than in childhood ALL (19/27 vs 0/29 cases, P < 0·001) and were highly associated with MLL gene rearrangement in infant ALL cases ( P < 0·001). These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL gene rearrangement in the development of infant ALL, which represents a distinct entity of childhood ALL.