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Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins
Author(s) -
Stark Batia,
Jeison Marta,
Preudhomme Claude,
Fenaux Pierre,
Ash Shifra,
Korek Yifat,
Stein Jerry,
Zaizov Rina,
Yaniv Issac
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03756.x
Subject(s) - trisomy , acute megakaryoblastic leukemia , monozygotic twin , trisomy 8 , medicine , gene rearrangement , myeloid leukaemia , immunology , leukemia , biology , cancer research , karyotype , genetics , chromosome , gene
Summary. An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML‐M7) in one and myelodysplasia transformed to AML‐M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML‐M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.