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Life‐threatening human parvovirus B19 infection transmitted by intravenous immune globulin
Author(s) -
Hayakawa Fumihiko,
Imada Kazumi,
Towatari Masayuki,
Saito Hidehiko
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03741.x
Subject(s) - parvovirus , fulminant , medicine , hepatitis b immune globulin , immunology , hydrops fetalis , hepatitis , fulminant hepatitis , immune system , aplasia , pure red cell aplasia , antibody , aplastic anemia , pregnancy , fetus , biology , virus , hepatitis b virus , bone marrow , lamivudine , genetics
Summary. Infection of human parvovirus B19 (B19) is usually a self‐limiting febrile illness, but can sometimes be life‐threatening under certain circumstances, such as aplastic crisis in patients with haemolytic anaemia, hydrops fetalis in pregnant women and fulminant hepatitis. B19 canbe transmitted through respiratory secretions, transplacentally and by transfusion of blood or blood products. In the present case, administration of intravenous immune globulin (i.v.Ig) transmitted B19 infection and consequently caused pure red cell aplasia and aggravation of hepatitis to fulminant hepatitis. Our case may raise important questions as to the safety of i.v.Ig and possible contamination by B19.