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Low‐dose, single‐fraction, whole‐lung radiotherapy for pulmonary hypertension associated with myelofibrosis with myeloid metaplasia
Author(s) -
Steensma David P.,
Hook C. Christopher,
Stafford Scott L.,
Tefferi Ayalew
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03695.x
Subject(s) - medicine , myelofibrosis , radiation therapy , pulmonary hypertension , metaplasia , lung , pulmonary artery , external beam radiotherapy , hypoxia (environmental) , radiology , pulmonary toxicity , myeloid , gastroenterology , cardiology , surgery , bone marrow , brachytherapy , chemistry , organic chemistry , oxygen
Summary. Pulmonary hypertension (PH) can complicate myelofibrosis with myeloid metaplasia (MMM), may arise in the absence of evidence for thromboembolic disease and carries a grim prognosis. Four patients with MMM and severe symptomatic PH were treated with whole‐lung external beam radiotherapy in a single fraction of 100 cGy. Within 72 h, each patient noted marked symptomatic improvement and had relief of hypoxia and reduction of oedema and/or ascites. Three of the four patients enjoyed an objective improvement in pulmonary artery systolic pressure as measured by transthoracic Doppler echocardiography. Low‐dose lung radiotherapy may be a useful palliative tool for patients with MMM complicated by PH.