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Impact of stem cell source and conditioning regimen on erythrocyte recovery kinetics after allogeneic haematopoietic stem cell transplantation from an ABO‐incompatible donor
Author(s) -
Kanda Yoshinobu,
Tanosaki Ryuji,
Nakai Kunihisa,
Saito Takeshi,
Ohnishi Mutsuko,
Niiya Hironari,
Chizuka Aki,
Yakushijin Kimikazu,
Urahama Norinaga,
Ueda Kyoji,
Iijima Kimiko,
Ando Toshihiko,
Matsubara Hiroshi,
Kami Masahiro,
Makimoto Atsushi,
Kobayashi Yukio,
Tobinai Kensei,
Mineishi Shin,
Takaue Yoichi
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03693.x
Subject(s) - abo blood group system , transplantation , stem cell , haematopoiesis , haemolysis , conditioning regimen , immunology , hematopoietic stem cell transplantation , biology , medicine , genetics
Summary. We evaluated erythrocyte recovery in 121 allogeneic haematopoietic stem cell transplantation (HSCT) recipients. There were 35 major and minor ABO‐incompatible transplants, respectively, including 10 bi‐directionally ABO‐incompatible transplants. The use of peripheral blood stem cells facilitated erythrocyte recovery, regardless of the presence or absence of major ABO‐incompatibility, and was associated with a frequent detection of anti‐host isohaemagglutin early after minor ABO‐incompatible transplantation, which was not associated with clinically relevant haemolysis. The use of a reduced‐intensity regimen combining a purine analogue and busulphan did not delay erythrocyte recovery after major ABO‐incompatible transplantation, suggesting this regimen had a strong activity against host plasma cell.