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Strontium‐89: a novel treatment for a case of osteosclerotic myeloma associated with life‐threatening neuropathy
Author(s) -
Sternberg Alexander J.,
Davies Paul,
Macmillan Craig,
AbdulCader Aboobucker,
Swart Sonia
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03692.x
Subject(s) - medicine , organomegaly , polyneuropathy , multiple myeloma , peripheral neuropathy , osteosclerosis , chemotherapy , surgery , pathology , endocrinology , diabetes mellitus
Summary. Osteosclerotic myeloma is a rare disorder characterized by paraproteinaemia and osteosclerosis, and may be associated with a progressive peripheral neuropathy. Patients with widespread osteosclerotic lesions can succumb from neurological complications despite systemic chemotherapy. We present a case of disseminated osteosclerotic myeloma associated with POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M band, skin changes) syndrome, which was complicated by a rapidly progressive, life‐threatening neuropathy. The patient's symptoms remained unchanged in the face of combination chemotherapy. However, a substantial improvement was seen following outpatient treatment with the commonly available radioisotope strontium 89 in combination with steroids.