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Etilefrine for the prevention of priapism in adult sickle cell disease
Author(s) -
Okpala Iheanyi,
Westerdale Neill,
Jegede Tina,
Cheung Betty
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03691.x
Subject(s) - priapism , medicine , sickle cell trait , hemoglobinopathy , complication , fulminant , disease , erectile dysfunction , anesthesia , pediatrics , surgery
Summary. Priapism is a common complication of sickle cell disease (SCD) that could lead to erectile dysfunction and psychosocial problems. Treatment of established fulminant priapism is usually not satisfactory. It is therefore important to prevent this complication of SCD. The alpha‐adrenergic agonist etilefrine (50–100 mg/d) produced a good clinical response in 13 of 18 (72%) adults who have recurrent priapism; 17 had SCD and one sickle cell trait. After a follow‐up of 1–48 months, none of the 18 people on etilefrine developed hypertension or sexual dysfunction. Similar efficacy and safety profiles of the drug have been reported previously.