Premium
A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission
Author(s) -
Ooi Jun,
Iseki Tohru,
Takahashi Satoshi,
Tomonari Akira,
Nagayama Hitomi,
Ishii Koji,
Ito Kiyoshi,
Sato Hiroyuki,
Takahashi Tsutomu,
Shindo Motohiro,
Sekine Rieko,
Ohno Nobuhiro,
Uchimaru Kaoru,
Nagamura Fumitaka,
Shirafuji Naoki,
Tojo Arinobu,
Tani Kenzaburo,
Asano Shigetaka
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03650.x
Subject(s) - medicine , transplantation , incidence (geometry) , bone marrow , haematopoiesis , conditioning regimen , cord blood , acute leukemia , surgery , hematology , graft versus host disease , leukemia , gastroenterology , hematopoietic stem cell transplantation , stem cell , physics , biology , optics , genetics
Summary. We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft‐versus‐host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease‐free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.