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Analysis of T‐cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantation
Author(s) -
Tsutsumi Yutaka,
Tanaka Junji,
Sugita Junichi,
Kato Naoko,
Zhang Li,
Yonezumi Masakatsu,
Chiba Kouji,
Toyosima Nobuyasu,
Kondo Takeshi,
Ohta Shuichi,
Mori Akio,
Hasino Satoshi,
Asaka Masahiro,
Imamura Masahiro
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03628.x
Subject(s) - pancytopenia , cd8 , aplastic anemia , t cell receptor , immunology , transplantation , bone marrow , medicine , immune system , t cell
Summary. We analysed 26 T‐cell receptor (TCR) β chain subfamilies (VB) of a patient with aplastic anaemia (AA) who underwent allogeneic bone marrow transplantation (allo‐BMT). The patient developed pancytopenia at d 80. The patient's T cells were skewed in 10 of 26 TCR‐VB on d 83. These TCR‐VB, especially VB15, which were almost entirely CD8‐positive cells, were skewed throughout her clinical course. Chimaerism analysis of the CD8‐positive cells indicated that they were of recipient origin. Therefore, some immune responses induced by the recipient CD8‐positive T cells had an important role in pancytopenia in AA patients after allo‐BMT.