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Spontaneous remission of low‐grade B‐cell non‐Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: case report and review of the literature
Author(s) -
Baird Richard D.,
Nellis van ZylSmit Richard,
Dilke Timothy,
Scott Sara E.,
Rassam Saad M. B.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03619.x
Subject(s) - medicine , methotrexate , rheumatoid arthritis , lymphoma , biopsy , surgery , bone marrow , stage (stratigraphy) , gastroenterology , paleontology , biology
Summary. A 69‐year‐old woman, who had suffered from deforming rheumatoid arthritis since the age of 40 years, had been treated with methotrexate for 3 years. She presented with a 7 week history of neck lymphadenopathy. Biopsy revealed low‐grade marginal‐zone B‐cell non‐Hodgkin's lymphoma. Computerized tomography and bone marrow biopsy confirmed stage IIIA disease. Spontaneous complete remission of the lymphoma was achieved 14 months after withdrawing immune suppression with methotrexate.