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Induction of HA‐1‐specific cytotoxic T‐cell clones parallels the therapeutic effect of donor lymphocyte infusion
Author(s) -
Kircher Brigitte,
Stevanovic Stefan,
Urbanek Martina,
Mitterschiffthaler Andrea,
Rammensee HansGeorg,
Grünewald Kurt,
Gastl Günther,
Nachbaur David
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03536.x
Subject(s) - donor lymphocyte infusion , immunology , minor histocompatibility antigen , medicine , cd8 , transplantation , cytotoxic t cell , chemotherapy , human leukocyte antigen , refractory (planetary science) , graft versus host disease , stem cell , disease , antigen , major histocompatibility complex , biology , biochemistry , genetics , astrobiology , in vitro
Summary. Donor lymphocyte infusions (DLI) can induce a graft‐versus‐leukaemia (GvL) reaction in patients with relapsed disease. However, the mechanisms involved in remission induction are not completely known. A patient with chemotherapy‐refractory relapse 1 year after human leucocyte antigen (HLA)‐identical, unrelated stem cell transplantation (SCT) for bcr/abl‐positive common acute lymphoblastic leukaemia (ALL) received a DLI from the original donor, and achieved complete cytogenetic and molecular remission concomitantly with extensive graft‐versus‐host disease (GvHD). Seven CD8 + , donor‐derived, alloreactive T‐cell clones were generated by stimulating post‐DLI remission cells with the patient's pretransplant mature dendritic cells. The minor histocompatibility antigen (mHag) recognized by these T‐cell clones was identified as HA‐1, a mHag associated with acute GvHD after SCT. Our finding provides evidence of HA‐1‐associated GvL effects after DLI that paralleled the eradication of full‐blown, chemotherapy‐refractory ALL relapse after allogeneic SCT.