Premium
Therapy‐related chronic myelogenous leukaemia following autologous stem cell transplantation for Ewing's sarcoma
Author(s) -
Numata Akihiko,
Shimoda Kazuya,
Gondo Hisashi,
Kato Kouji,
Aoki Kenichi,
Ito Yoshikiyo,
Takase Ken,
Asano Yoshinobu,
Okamura Takashi,
Niho Yoshiyuki,
Harada Mine
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03517.x
Subject(s) - medicine , stem cell , autologous stem cell transplantation , chemotherapy , transplantation , sarcoma , chronic myelogenous leukemia , bone marrow , oncology , cancer research , leukemia , pathology , immunology , biology , genetics
Summary. A 17‐year‐old Japanese woman with Ewing's sarcoma was initially treated with conventional chemotherapy and local irradiation, and then with high‐dose chemotherapy supported by autologous peripheral blood stem cell transplantation. Four years later she was diagnosed with chronic myelogenous leukaemia (CML). The BCR/ABL fusion gene was detected in both peripheral blood and bone marrow cells by reverse transcription–polymerase chain reaction, but not in the harvest product of peripheral blood stem cells which were infused at the time of transplantation. This case adds to the accumulating evidence of therapy‐related CML developing after high‐dose chemotherapy and autologous stem cell transplantation.