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Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA‐100 ® ) *
Author(s) -
Carcao Manuel D.,
Blanchette Victor S.,
Stephens Derek,
He Lijing,
Wakefield Cindy D.,
Butchart Sheila,
Christie Douglas J.,
Rand Margaret L.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03511.x
Subject(s) - platelet , medicine , platelet disorder , blood platelet disorders , mean platelet volume , platelet transfusion , nuclear medicine , spectrum analyzer , platelet aggregation , physics , optics
Summary. The Platelet Function Analyzer (PFA‐100 ® ) was used to measure platelet function in paediatric patients with destructive versus underproduction thrombocytopenia. Closure time (CT) and total volume (TV) measurements with standard 150 μm apertures discriminated between patients with similar platelet counts from 30 to 150 × 10 9 /l. However, at platelet counts < 30 × 10 9 /l, a 100‐μm aperture (experimental) gave the best assessment of platelet function. TV results could be analysed even when CTs were indeterminate. Further investigations are warranted to more fully understand the relationships among platelet function as measured by the PFA‐100 ® in standard/experimental modes, bleeding and transfusion outcome in thrombocytopenia.