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Stevens–Johnson syndrome after treatment with STI571: a case report
Author(s) -
Hsiao LiangTsai,
Chung HungMing,
Lin JenTsun,
Chiou TzeonJye,
Liu JinHwang,
Fan Frank S.,
Wang WeiShu,
Yen ChuehChuan,
Chen PoMin
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03499.x
Subject(s) - medicine , chronic myeloid leukaemia , blast crisis , adverse effect , dermatology , pediatrics , myeloid
Summary. Between seven and 21% of patients treated with the specific tyrosine kinase inhibitor STI571 have been reported to develop mild‐to‐moderate severity of adverse cutaneous reactions. We report a patient in the blast crisis phase of chronic myeloid leukaemia who developed a life‐threatening cutaneous reaction, Stevens–Johnson syndrome, following 1 week of STI571 therapy. This report may serve to remind the clinician about the possible severe cutaneous side‐effects of STI571 before instituting more extensive clinical application of this agent in the future.