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Deletion of sequences flanking the t(9;22) breakpoint: a secondary genetic event associated with loss of cytogenetic response to interferon in a Philadelphia‐positive chronic myeloid leukaemia patient
Author(s) -
Arranz Eva,
GilFernández Juan José,
Ramiro Soraya,
Blas Carlos,
Renedo Mónica,
Alegre Adrián,
Escudero Antonio,
FernándezRañada Jose María
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03432.x
Subject(s) - breakpoint , chromosomal translocation , biology , cytogenetics , philadelphia chromosome , genetics , myeloid , chromosome abnormality , chromosome , karyotype , cancer research , microbiology and biotechnology , gene
Summary. We present a Ph‐positive chronic myeloid leukaemia patient who lost a complete cytogenetic response (CCR) of 23 months duration at the time of detection of a deletion, not previously observed, of chromosomes 9 and 22 sequences flanking the translocation breakpoint on the derivate 9 chromosome. To our knowledge, this is the first case in which a deletion at the t(9;22) breakpoint has arisen as a secondary genetic alteration produced after formation of the t(9;22) translocation. It remains to be determined whether this genetic abnormality has the same prognostic importance as when observed at diagnosis.