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FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance
Author(s) -
Rasmussen Thomas,
Hudlebusch Heidi Rye,
Knudsen Lene Meldgaard,
Johnsen Hans Erik
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03429.x
Subject(s) - multiple myeloma , relevance (law) , medicine , oncology , political science , law
Summary. The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14·5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow‐up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival ( P = 0·3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.