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Cultured autografting for juvenile myelomonocytic leukaemia
Author(s) -
Grainger John D.,
Will Andrew M.,
Stevens Richard F.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03415.x
Subject(s) - juvenile myelomonocytic leukemia , stem cell , clone (java method) , chromosomal translocation , transplantation , bone marrow , medicine , cancer research , biology , surgery , immunology , oncology , haematopoiesis , genetics , dna , gene
Summary. A case of juvenile myelomonocytic leukaemia (JMML) associated with a chromosomal translocation (1;5) is described. Initial cytoreductive therapy failed to control the disease. In the absence of a matched family or unrelated donor, a Dexter‐type long‐term bone marrow culture (LTBMC) was established. The LTBMC showed preferential growth of normal stem cells over the abnormal clone, allowing a cultured autologous stem cell transplantation to be performed. Despite detection of the t(1;5) from 5 months to 7 years following cultured autograft, the patient remained in haematological remission. Currently the patient is alive and well at 10 years in full cytogenetic remission.